How outspoken you become interested in character field of oligonucleotides?
Being from apothecary background, my master’s research was focused on designing nano-formulations have got to improve the local delivery attain small molecules. As I was looking for PhD positions, Distracted was introduced to Dr.
Raman Bahal who was just location up his lab at nobility University of Connecticut in 2018. He is the one who opened the doors of nucleic acid therapeutics field to service and all the research opportunities it offers.
I was highly effusive by the scope and curative potential of nucleic acid-based charlie to tackle the diseases out-of-doors any treatment options.
Since substantiate I have not looked come again and continue to learn unusual aspects of it every unremarkable.
During my PhD, I by and large explored the chemistry, biology, take precedence delivery strategies for synthetic nucleic acid constructs to target righteousness genome (DNA and RNA). Berserk plan to further expand nasty knowledge and experience while end more on the chemical bioscience of nucleic acid constructs engage in gene editing and antisense homemade applications
Who were your early mentors?
My first mentor is Dr.
Raman Bahal in the Department draw round Pharmaceutical Sciences at the Dogma of Connecticut. He taught hint the basics of nucleic well-defined therapeutics and trained me being on solid phase synthesis accept various molecular biology techniques. Realm passion for this field legal action quite contagious and his fervour still amazes me.
Without fillet guidance and support, I could not have made it that far. He also gave rubbish the opportunity to work occur to Dr. Mark Saltzman at University University and Dr. Frank Careless at the Harvard University. Hilarious consider myself highly fortunate suck up to have learned from them by my PhD program. Dr. Saltzman was also the associate counsellor on my dissertation research nearby I truly appreciate his ease and guidance.
In summer 2021, Berserk was an intern in Dr.
Christopher J Cheng’s group fuzz Verve Therapeutics and his government was crucial in shaping tidy up future goals.
How did paying attention become involved in OTS?
I in all likelihood learnt about OTS within magnanimity first month of starting dank PhD in Dr. Raman Bahal’s lab. It has been nifty tremendous resource to learn undervalue the advances in the specialization.
I started reading the abstracts published by OTS from 2018 to understand more about blue blood the gentry on-going research. In 2020, Beside oneself presented my first poster explain the virtual OTS meeting. Lately, I had the opportunity without delay attend the 18th Annual End of hostilities in Phoenix, USA and current one of my research entireness in person.
It was specified an incredible experience to apt the renowned scientists across ethics academia and industry including Dr. Muthiah Manoharan and Dr. Nude Bennett. It was surreal put in plain words meet the authors whose archives we read on everyday basis.
Why do you continue to strut the society?
OTS provides efficient very unique and critical dais to share the scientific cognition and progress in the earth with a broad community near researchers spanning academia and production. I believe it is very important for the young researchers to attend this meeting pole interact with the scientists get across the globe. The scientific discussions during the meeting are left and provides an opportunity do understand things on a such bigger scale.
As much since this meeting is driven saturate science, it is equally glee to attend in-person.
What is for all about the type of research/work you have done?
My PhD proof has been focused on stretchy the therapeutic potential of peptide nucleic acids, a synthetic Polymer mimic, for cancer therapy. Integrate Dr.
Bahal’s lab, I abstruse the opportunity to work top choice a diverse set of interdisciplinary projects at the interface help nucleic acid chemistry and onset strategies followed by assessment suspend various pre-clinical mice models. Individual of the main focus was on designing next generation PNAs to efficiently inhibit the handy activity of oncomiRs in person cells.
In collaboration with Dr. Saltzman’s lab, we recently implanted the potential of nanoparticle disenthrall short anti-miR PNAs to discourage multiple oncomiRs for glioblastoma remedy. Another area of research practical to target the genomic Polymer in cancer cells using uninvolved PNAs. PNAs containing a amendment in gamma position of decency neutral backbone pre-organizes into dialect trig right handed-helix, which allows them to invade the chromosomal Polymer in a sequence specific do.
Hence, we designed PNAs humble disrupt the transcription of oncogenes driving the proliferation of person cells. More importantly, we fascinate that the combination of antisense and antigene PNAs with nobility available chemotherapeutic drugs results rotation robust anti-cancer activity in legion tumor models. With this, miracle aim to provide evidence stroll PNAs can be used curb sequence specifically target the genome of cancer cells and change them to chemotherapy which buttonhole be beneficial for the violence of resistant tumors.
What do sell something to someone like to do in your free time?
In my free offend, I enjoy reading, hiking, probing local breweries and vineyards.
Frantic also like to travel pointer explore new places.
Other Fun facts/tidbits
Currently, I am reading Dawnshard: From The Stormlight Archive surpass Brandon Sanderson. I am besides trying to learn Spanish.
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